RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
CLDN5
RNA ID
RNA Type
mRNA
Alteration Pattern
dna methylation
Species
homo sapiens
Detection Methods
MSP; qRT-PCR; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Altered DNA methylation profile in idiopathic pulmonary fibrosis
Year
2012
Function
"IPF samples demonstrated higher DNA methyltransferase expression without observed alterations in global DNA methylation. Among the genes whose DNA methylation status and RNA expression were both significantly altered, 16 genes were hypermethylated in DNA associated with decreased mRNA expression or vice versa.Changes in DNA methylation correspond to altered mRNA expression of a number of genes, some with known and others with previously uncharacterized roles in IPF, suggesting that DNA methylation is important in the pathogenesis of IPF."